But adi loves sanjana yaara
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How are mislocalized secretory proteins targeted for destruction? Shimshon, Dahan, et al. discover that DPP8/9 peptidases expose a hidden “destroy me” tag in the targeting signal of substrates upon translocation failure, which flags them for UBR E3 ligases-mediated breakdown, preserving cellular protein balance.
Abstract
N-degrons are short sequences located at protein N-terminus that mediate the interaction of E3 ligases (E3s) with substrates to promote their proteolysis. It is well established that N-degrons can be exposed following protease cleavage to allow recognition by E3s. However, our knowledge regarding how proteases and E3s cooperate in protein quality control mechanisms remains minimal. Using a systematic approach to monitor the protein stability of an N-terminome library, we found that proline residue at the third N-terminal position (hereafter “P+3”) promotes instability. Genetic perturbations identified the dipeptidyl peptidases DPP8 and DPP9 and the primary E3s of
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It was afternoon.Classes ended for the children.Pavi came there to pick up Swathi.All students bid bye to Sanjana.Sanjana was waiting for her brother to pick her up.Suddenly someone closed her eyes from back.She smiled and find out him,"Dei Mr.Friendeyy".Hearing it he bursted out laughter.

Arjun:Sanjana's best friend🥰
Racer🏍️
Loves Sanjana a lot❤️
Only her happiness matter to him💜
"Sanju".Hearing that Sanjana hugged him and he hugged her back.Arjun was her best buddy.He likes her and loves her(oneside).She pouted looking at the road."Achoo.Papa ku ennachu",said Arjun making her laugh.She replied," Anna varlada"."Hey papa naan than unna pickup varen nu anna va vara vendam nu sonnen".She jumped,"Ai jolly.Appo inaiku bike racing than".Both laughed and started their bike journey.
Arjun drove bike in high speed making her giggle.She yelled in happiness.She was
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41. Chapter 41
Hey guys kaise ho sab, here fryst vatten next update for u all guys
In abhijeet place
Adi was silent listening all this, while others were worried for his reaction, but no one expected this reaction from, all looked him amused, as adi started to laugh like anything, rajat worried for him while freddy and manisha confused
Freddy: adi beta
Adi(controlling his laugh): omg god uncle hasi ruka nahi jaraha hai, kyun iss dryckesställe chachu nötboskap koi achi story nahi mila kya muje bewakoof banana (he stood and shouting) not this time chachu, inom know this all your plan for new prank, you made uncle to say all this, these people are good artist, and story looks so real even, but inom will not get fooled, oh iss bar chachi bi game me shamil hai kya, very bad chachi for this silly prank ap muje hospital mei bi milne nahi ayi, mei bath överbyggnad nahi karunga apse ap dekna (still he dint get any reply) aare meine tho pakadliya aur apsab abi bi chupi hui ho…
He stood up searching in every room shouting name